There is a wide range of proteins containing nucleotide-binding domains and leucine-rich repeats (NLR proteins) in animals and plants. Although these NLR resistance proteins have been reported to function as receptors for plant immune responses as early as 15 years ago, the mechanism by which they activate downstream defense responses remains unclear. In July 2010, the Zhang Yuelin laboratory of the Beijing Institute of Life Sciences published an article in PNAS magazine that reported that the Arabidopsis resistance protein SNC1 interacts with the transcriptional co-repressor TPR1 to inhibit negative regulatory factors in plant disease defense , Thereby activating the molecular mechanism of the plant immune response mediated by the resistance protein. Zhu Zhaohai, a doctoral student jointly recruited by the Beijing Institute of Life Sciences and China Agricultural University, is the first author of the paper. Other authors include doctoral students Xu Fang and Cheng YuTi of UBC University in Canada, Dr. Marcel Wiermer, Dr. Li Xin, and Dr. Zhang Yaxi of the Beijing Institute of Life Sciences. Dr. Zhang Yuelin of the Beijing Institute of Life Sciences is the corresponding author of this paper. The research was funded by the Ministry of Science and Technology and the Beijing Municipal Science and Technology Commission and was completed at the Beijing Institute of Life Sciences. This study found that the TIR-NB-LRR resistance protein SNC1 in Arabidopsis thaliana regulates plant disease resistance through its interacting protein TPR1. Knocking out TPR1 and its homologous genes resulted in a weakened plant immune response mediated by SNC1 and other TIR-NB-LRR resistance proteins. The overexpression of TPR1 constitutively activates the immune response mediated by SNC1. As a transcriptional co-repressor, TPR1 regulates plant disease resistance by interacting with histone deacetylase HDA19 in plants. Using chromatin immunoprecipitation, we found two target genes, DND1 and DND2, for TPR1. They are negative regulators of plant immune response, and their expression is suppressed early in the plant's defense response to disease. The above results indicate that SNC1 inhibits DND1 and DND2 and other negative regulatory factors through its interaction protein TPR1, thereby activating the plant immune response mediated by the resistance protein. Best choice running track artificial turf synthetic lawn for runway LUXGMD20 Best choice running track artificial turf synthetic lawn for runway high-quality grass fiber material which include anti-aging and anti-UV content , and the use of international advanced technology .. The runway artificial turf grass refined with natural grass similar to the appearance and performance, with good elasticity, good pressure after the recovery of good, flexible wear, fire,Aging, thermal insulation, drainage speed, anti-UV, anti-corrosion, mildew, environmental protection, easy maintenance, etc. Artificial Sports Turf,Runway Artificial Grass,Runny Way Grass,Runway Grass Shandong Shangkun Sports Health Technology Co.,Ltd. , http://www.shangkunsports.com