The recent hype around chloroquine and hydroxychloroquine as potential treatments for COVID-19 has led some to confuse them with quinine, wrongly assuming that quinine can also be used to fight the virus. This is a dangerous misunderstanding. While all three are related in structure and history, they are not interchangeable. There's no scientific evidence that quinine is effective against SARS-CoV-2, and using it without medical supervision could be harmful. Chloroquine and hydroxychloroquine, on the other hand, have shown some promise in early studies. Both are long-standing antimalarial drugs, and they've been used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers first reported on their potential against COVID-19 in early February, suggesting that they might work by altering the pH of cellular compartments, which could prevent the virus from replicating inside cells. Since then, more data has emerged, including in-vitro experiments, case reports, and even a non-randomized trial from China. In that study, patients treated with chloroquine and azithromycin turned PCR-negative within seven days, while many in the control group remained positive. However, the study had limitations—like an as-treated analysis rather than intent-to-treat—which may have skewed the results. Still, the findings were compelling enough to prompt some countries to begin using these drugs under strict guidelines. In South Korea and Japan, for example, doctors have started prescribing limited doses of chloroquine or hydroxychloroquine for severe cases. China is reportedly moving toward making it a standard treatment. In the U.S., the CDC has advised caution, urging physicians to wait for more robust clinical trials before using these drugs outside of research settings. But some doctors have already used them in life-threatening situations, reflecting the urgency of the pandemic. Despite the growing interest, there are serious risks. In Nigeria, several people were hospitalized due to chloroquine overdoses, and in the U.S., a couple died after ingesting chloroquine meant for fish tanks. These tragic incidents highlight the dangers of self-medicating. The president’s public endorsements of these drugs may have contributed to increased demand, but the supply chain is still stable. Companies like Bayer and Sanofi are ramping up production, and millions of people take chloroquine daily for malaria, ensuring global availability. Still, it’s important to remember: if these drugs do work, they will help treat those who are already sick—not prevent infection. Most infections happen before symptoms appear, so they won’t stop the spread entirely. And they’re unlikely to be needed for mild cases, which make up the majority of infections. Even if they prove effective, they won’t end the pandemic alone. For now, the best advice is to stay informed, follow official guidance, and avoid taking unproven medications. Quinine, meanwhile, should remain in the gin and tonic—never as a substitute for real medicine.
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