Guide Huntington's chorea causes memory loss and cognitive impairment, affecting learning ability, and there is currently no cure. The latest study has finally identified the main cause of the disease – directly related to brain urea levels and metabolic processes, which will have an important impact on diagnosis and treatment. Discovery of the cause Huntington's disease is one of the four most common neurodegenerative diseases (the other three are Alzheimer's, Lugarray's, Parkinson's). Professor Garth Cooper of the Department of Cardiology at the University of Manchester said that we know that Huntington's disease is a disease caused by genetic defects, but until now, we still don't know how it causes brain damage. Urea and ammonia in the brain are metabolic breakdown products of proteins. If urine and ammonia are not discharged, accumulation in the body can cause serious symptoms. The researchers used human brains (donations) and Australian genetically modified sheep for medical research, and used peak gas chromatography mass spectrometry to measure brain urea levels. And in order to achieve toxic urea levels, urea must be four times higher or higher than in normal brain. It was found that Huntington's disease is directly related to brain urea levels and metabolic processes. The findings were published in the Proceedings of The National Academy of Sciences on December 11. Professor Cooper said: This study unveiled the secret of Huntington's disease, and high concentrations of brain urea play a key role in the disease. Expected to reverse dementia In fact, as early as 2016, Professor Cooper determined the metabolic relationship between Huntington's disease, other neurodegenerative diseases and type 2 diabetes. They found that urea levels are associated with Alzheimer's disease. We know that Alzheimer's disease and Huntington's disease are completely different in the dementia lineage. If urea is the same for both diseases, then we believe that it is likely to be age-related. Dementia is explained. According to Cooper, the findings are landmark and have a profound impact on our understanding of the molecular basis of dementia and its treatment. Of course, researchers need more research to confirm the source of high concentrations of urea. Now doctors can use drugs to treat high concentrations of ammonia in the body. For example, lactulose, a commonly used laxative, can reduce the formation of ammonia in the intestines. Perhaps one day in the future, a common drug can stop dementia. So it seems that reversing dementia will be far behind? Shanghai Chuangsai Technology has excellent performance, interleukin cytokines, fetal bovine serum, electrophoresis equipment scientific instruments, raw material drug standards, chemical reagents, cell culture consumables, Shanghai Chuangsai, mass products special promotions, welcome to inquire! Decor Globe,Decorative Desktop Globe,Desktop Globe With Stand,Vintage Decorative Globe Ningbo Holly Arts & Crafts Co.,Ltd. , https://www.china-globes.com