Stem cells use a first aid kit to repair cell damage

Researchers led an international team that demonstrated that stem cells pass molecules through the fluid in the vesicles to "communicate" with other cells to help them improve the surrounding unwanted immune response. In stem cells, these tiny vesicles are like a miniature 'first aid kit' with molecules such as proteins and nucleic acids that stimulate the target cells and help them survive. Basically, vesicles draw on how stem cells respond to the inflammatory environment and pass this ability to target cells. ”

In mice with multiple sclerosis, the researchers injected neural progenitor cells (NPCs, a neural stem cell) into the mouse circulatory system, and their brain cells showed extraordinary levels of repair. This suggests that NPCs release molecules that regulate the immune system, ultimately reducing tissue damage and enhancing tissue repair.

The team has now demonstrated that when NPCs are in the vicinity of the immune response, especially when reacting with gamma-interferon released by immune cells, vesicles are released, and gamma interferon regulates immune responses and inherent brain repair procedures, which can be used in NPCs. Triggers a highly specialized gene activation pathway that also binds to a receptor on the surface of the vesicle. When the vesicles are released by the NPCs, they adhere to the target cells, so that the target cells can not only obtain proteins and nucleic acids to promote repair, but also obtain gamma interferon on the surface of the vesicles and activate their own internal genes.

Scientists have speculated that stem cells may behave more like drugs. This study is the first to prove this molecular mechanism: discerning signals, moving to specific parts of the body and performing complex reactions. An in-depth understanding of this process will help researchers find ways to maximize the efficacy of stem cells.

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